DR GHK-CU

LEVEL 05 — CITATION INDEX

GHK-Cu Research: Full Reference Index

Full reference list for GHK-Cu research — 22 citations indexed with PubMed URLs, DOIs, and journal details. Every claim in this digest links to a numbered entry below.

All GHK-Cu citations used across this site are listed below in indexed order. Every quantitative claim in the research, dosage, and FAQ pages maps to a numbered entry here. For GHK-Cu wound healing studies citations, see entries 14 and 15. For collagen research citations, see entries 1, 2, 5, and 9. For the gene expression record, entries 4 and 8.

  1. [01]
    Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Letters. 1988;238(2):343-346. DOI: 10.1016/0014-5793(88)80509-x PMID: 3169264 Full Text ↗
  2. [02]
    Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International. 2015;2015:648108. DOI: 10.1155/2015/648108 PMID: 26236730 Full Text ↗
  3. [03]
    Pickart L, Vasquez-Soltero JM, Margolina A. The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxidative Medicine and Cellular Longevity. 2012;2012:324832. DOI: 10.1155/2012/324832 PMID: 22666519 Full Text ↗
  4. [04]
    Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International. 2015;2015:648108. DOI: 10.1155/2015/648108 PMID: 26236730 Full Text ↗
  5. [05]
    Mortazavi SM, Mohammadi Vadoud SA, Moghimi HR. Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective. BioImpacts. 2024;14:30071. DOI: 10.34172/bi.30071 PMID: 39963574 Full Text ↗
  6. [06]
    Hostynek JJ, Dreher F, Maibach HI. Human skin penetration of a copper tripeptide in vitro as a function of skin layer. Inflammation Research. 2010;59(11):983-988. DOI: 10.1007/s00011-010-0238-9 PMID: 20721598 Full Text ↗
  7. [07]
    Tucker M, Keely A, Park JY, Rosenfeld M, Wezeman J, Mangalindan R, Ratner D, Ladiges W. Intranasal GHK peptide enhances resilience to cognitive decline in aging mice. bioRxiv (preprint). 2023. DOI: 10.1101/2023.11.16.567423 PMID: 38014118 Full Text ↗
  8. [08]
    Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences. 2018;19(7):1987. DOI: 10.3390/ijms19071987 PMID: 29986520 Full Text ↗
  9. [09]
    Jiang F, Wu Y, Liu Z, Hong M, Huang Y. Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests. Journal of Cosmetic Dermatology. 2023;22(9):2469-2475. DOI: 10.1111/jocd.15763 PMID: 37062921 Full Text ↗
  10. [10]
    Lee WJ, Sim HB, Jang YH, Lee SJ, Kim DW, Yim SH. Efficacy of a Complex of 5-Aminolevulinic Acid and Glycyl-Histidyl-Lysine Peptide on Hair Growth. Annals of Dermatology. 2016;28(4):438-443. DOI: 10.5021/ad.2016.28.4.438 PMID: 27489425 Full Text ↗
  11. [11]
    Zhou XM, et al. GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFbeta1/Smad-Mediated Epithelial-to-Mesenchymal Transition. Frontiers in Pharmacology. 2017;8:904. DOI: 10.3389/fphar.2017.00904 PMID: 29311918 Full Text ↗
  12. [12]
    Zhang Q, Yan L, Lu J, Zhou X. Glycyl-L-histidyl-L-lysine-Cu2+ attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative stress pathway. Frontiers in Molecular Biosciences. 2022;9:925700. DOI: 10.3389/fmolb.2022.925700 PMID: 35936787 Full Text ↗
  13. [13]
    Mao S, Huang J, Li J, Sun F, Zhang Q, Cheng Q, Zeng W, Lei D, Wang S, Yao J. Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms. Frontiers in Pharmacology. 2025;16:1551843. DOI: 10.3389/fphar.2025.1551843 PMID: 40672369 Full Text ↗
  14. [14]
    Pickart L. The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition. 2008;19(8):969-988. DOI: 10.1163/156856208784909435 PMID: 18644225 Full Text ↗
  15. [15]
    Wang X, Liu B, Xu Q, Sun H, Shi M, Wang D, Guo M, Yu J, Zhao C, Feng B. GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis. Wound Repair and Regeneration. 2017;25(2):229-239. DOI: 10.1111/wrr.12520 PMID: 28370978 Full Text ↗
  16. [16]
    Jose S, Hughbanks ML, Binder BYK, Ingavle GC, Leach JK. Enhanced trophic factor secretion by mesenchymal stem/stromal cells with Glycine-Histidine-Lysine (GHK)-modified alginate hydrogels. Acta Biomaterialia. 2014;10(5):1955-1964. DOI: 10.1016/j.actbio.2014.01.020 PMID: 24468583 Full Text ↗
  17. [17]
    Lane TF, Iruela-Arispe ML, Johnson RS, Sage EH. SPARC is a source of copper-binding peptides that stimulate angiogenesis. Journal of Cell Biology. 1994;125(4):929-943. DOI: 10.1083/jcb.125.4.929 PMID: 7514608 Full Text ↗
  18. [18]
    Tucker M, Liao GY, Park JY, Rosenfeld M, Wezeman J, Mangalindan R, Ratner D, Darvas M, Ladiges W. Behavioral and neuropathological features of Alzheimer's disease are attenuated in 5xFAD mice treated with intranasal GHK peptide. bioRxiv (preprint). 2023. DOI: 10.1101/2023.11.20.567908 PMID: 38045355 Full Text ↗
  19. [19]
    Pickart L, Vasquez-Soltero JM, Margolina A. The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline. Brain Sciences. 2017;7(2):20. DOI: 10.3390/brainsci7020020 PMID: 28212278 Full Text ↗
  20. [20]
    Bian Y, Deng M, Liu J, et al. The glycyl-l-histidyl-l-lysine-Cu2+ tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6. Redox Biology. 2024;74:103237. DOI: 10.1016/j.redox.2024.103237 PMID: 38879894 Full Text ↗
  21. [21]
    Molavi AM, Sadeghi-Avalshahr A, Nokhasteh S, Naderi-Meshkin H. Enhanced biological properties of collagen/chitosan-coated poly(epsilon-caprolactone) scaffold by surface modification with GHK-Cu peptide and 58S bioglass. Progress in Biomaterials. 2020;9(1-2):35-46. DOI: 10.1007/s40204-020-00129-0 PMID: 32248401 Full Text ↗
  22. [22]
    Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes? Molecules. 2025;30(1):136. DOI: 10.3390/molecules30010136 PMID: 39795193 Full Text ↗